Endocrine Abstracts

Introduction: Pituitary adenomas are mostly benign tumors which may be clinically functioning or non-functioning and ACTH secreting tumors make up 15% of them. Up to 20% of corticotroph adenomas which don’t have any biochemical or clinical evidence of hypercortisolism are known as silent corticotroph adenomas.Case 1: A 54 years old male presented with blurred of vision and headache that increasing in severity within six years. Physical examination a...

Objectives: Pituitary gland is an uncommon site for metastasis of malignant tumors. Breast and lung are the most common cancer sites. Most pituitary metastases are asymptomatic, with only 7% symptomatic and central diabetes insipidus is the most common symptom.Case presentation: A 54 year-old woman presented with nause, emesis and diplopia to emergency department. Her relatives stated that she had poliuria, nocturia, polidipsia for three months. Her hist...

Due to inhibition affect on proliferation, motility, resistance to apoptosis and growth of metastasis, the epidermal growth factor receptor (EGFR) inhibitor erlotinib and vascular endothelial growth factor receptor (VEGF) and EGFR inhibitor vandetanib are viable treatment options for treatment of advanced non-small cell lung cancer and thyroid cancer respectively. Advanced non-small cell lung carcinomas (NSCLC) or medullary and differentiated thyroid carcinomas (MTC and DTC) m...

Introduction: Bilateral adrenal mass presents a unique diagnostic challenge and carries additional risk of being metastasis. The differential diagnosis of bilateral adrenal mass include primary or secondary neoplastic disorders (adrenocortical carcinoma, lymphoma, metastases), pheochromocytoma, longstanding congenital adrenal hyperplasia and macronodular adrenal hyperplasia, infections such as tuberculosis, histoplasmosis and blastomycosis.Case: Thirty-f...

Introduction: Diabetic foot is one of the important and destructive complications of diabetes. During the life time of a diabetic patient, the risk of developing foot ulcers is around 5–15%, and about 20–25% of the causes of hospitalization in diabetic patients are due to foot ulcers. 40–80% of foot ulcers can be infected and resulted in osteomyelitis. Hospitalization due to osteomyelitis is 12 times more in diabetic patients than in non-diabetic population....

Introduction: Minimally invasive surgery is an alternative surgical approach for primary hyperparathyroidism with less surgical trauma and anesthesia complications. Neck ultrasonography and scintigraphy are still the first step tools for localisating parathyroid lesions. Intact parathyroid hormone (PH) determination in washout samples is really very useful when parathyroid lesions can not be easily distinguished from thyroid lesions or sometimes lymph nodes.<p class="abste...

Introduction: Disease control in acromegaly can be achieved by surgery, medical treatment, and radiotherapy either alone or in combination. The acromegaly patients whom tumour shrinkage cannot be provided or growth hormone levels do not decrease under multiple treatment modalities are designated as resistant acromegaly. We aimed in our study to evaluate the clinical features of resistant acromegaly patients and determine their responds to different treatment modalities.<p ...

Expression of hormones other than GH may affect the prognosis in acromegalic patients. Generally, Ki-67 is a well-known proliferative index used to predict remission in pituitary adenomas. We aimed to evaluate the relationship of immunohistochemical expression pituitary hormones, ki-67 and remission. Also we evaluated the role of pre, post-operative clinical and laboratory values, pathological characteristics on long-term remission. We included 64 acromegaly patients that were...